The results of this study indicate that using a dual-lumen peripheral catheter, such as the Twin Cath, may allow solutions incompatible due to pH to be administered simultaneously. All the drug combinations used in this study have been reported to be incompatible at the concentrations tested however, we detected no incompatibilities. However, in phase II, because of the buffering capacity that plasma proteins add to plasma, no precipitation occurred. Phase I experiments showed immediate precipitation in Normosol-R within the venous flow. Compatibility was defined as no visual evidence of precipitation and no more than 15% mean change in final versus initial concentration. Samples were visually inspected at each time point for precipitation and analyzed in duplicate by the appropriate stability-indicating HPLC method (except for sodium bicarbonate). All samples were obtained immediately before the start of the infusion and at 5, 10, and 15 minutes during the infusion, and 5 minutes after the infusion. Phase I used Normosol-R as the diluent to gather preliminary data phase II used human plasma. Home IV Access VetCath DeltaMed Jugular Catheters Jugular Catheter, Double Lumen.

Study solutions were primed with the prepared drug solution and administered for 15 minutes. Ondansetron was simultaneously infused with fluorouracil, aminophylline, sodium bicarbonate, and ampicillin sodium in concentrations reflective of clinical conditions into the Twin Cath 20/22 (the dual-lumen catheter used in this experiment). To determine the degree to which a dual-lumen peripheral catheter prevented precipitation of solutions known to be incompatible due to pH during simultaneous infusion in an in vitro model.Īn in vitro model was devised to simulate peripheral venous blood flow from an antecubital source to systemic circulation.

Double lumen iv line